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  • Evidence is increasing that most addiction without exception is related to problems with the brain's reward center, especially the mesolimbic system. This section of the problem regulates reward responses in acquiring food and sex, along with nurturing infants and children. One of the most important neurotransmitters involved in reward responses, both after they malfunction and when they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the volume of dopamine released in responding to a stimulus"(Bostwick & Bucci, 2008).

    Using two separate drugs to lose weight naturally can be very effective you'll find combinations as you're watching FDA now awaiting approval. When dealing with weight-loss and the those who go through it you ought to err along the side of caution and allow FDA do its job and demand some research be done so that the public recognizes the side effects and dangers of the medications before we drive them. Keep in mind that drug companies will be in business to make money and that they would say everything to keep people on their medications.

    Researchers found that participants investing in this drug to get a year, lost weight within four weeks and have kept the load off through the entire 56 weeks from the study. Contrave is a combination from the drugs naltrexone and bupropion, which seems to reflect a new trend of weight-loss drugs which can be made up of more than one active ingredient, which may make them more effective and safer.

    Combo-pilling will be the newest fad or even better the newest into the future under scrutiny and so it is just more publicly known lately, comb-pilling for weight loss has been around since the eighties. The biggest reason that employing a combination of pills is now popular could be the fact that by right now there are no long term prescription diet pills that have been licensed by the FDA besides orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications although some people might of the combinations happen to be rejected or have yet to be approved by the FDA.

    Seizures certainly are a side effect with Contrave and really should not be taken in people with seizure disorders. The drug could also raise blood pressure level and heartbeat, and mustn't be used in individuals with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with all the drug.

    The FDA also warned that Contrave can raise blood pressure level and heart rate and must stop used in patients with uncontrolled high hypertension, and also by anyone with heart-related and cerebrovascular (blood vessel dysfunction impacting mental performance) disease. Patients having a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes having a boxed warning to alert medical researchers and patients for the increased chance of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stop smoking.

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